0061 : Exercice training impaired energy metabolism and function of the type 2 diabetic Goto-Kakizaki (GK) rat heart during ischaemiareperfusion injury
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منابع مشابه
Exercise training enhanced myocardial endothelial nitric oxide synthase (eNOS) function in diabetic Goto-Kakizaki (GK) rats
BACKGROUND Different mechanisms of diabetic-induced NO dysfunction have been proposed and central to most of them are significant changes in eNOS function as the rate-limiting step in NO bioavailability. eNOS exists in both monomeric and dimeric conformations, with the dimeric form catalyzing the synthesis of nitric oxide, while the monomeric form catalyzes the synthesis of superoxide (O2-). Di...
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Both Type 2 diabetes mellitus (T2DM) and estrogen deprivation have been shown to be associated with the development of cardiovascular disease and adverse cardiac remodeling. However, the role of estrogen deprivation on adverse cardiac remodeling in nonobese T2DM rats has not been clearly elucidated. We hypothesized that estrogen-deprivation aggravates adverse cardiac remodeling in Goto-Kakizaki...
متن کاملRegenerating 1 and 3b Gene Expression in the Pancreas of Type 2 Diabetic Goto-Kakizaki (GK) Rats
Regenerating (REG) proteins are associated with islet development, β-cell damage, diabetes and pancreatitis. Particularly, REG-1 and REG-3-beta are involved in cell growth/survival and/or inflammation and the Reg1 promoter contains interleukin-6 (IL-6)-responsive elements. We showed by transcriptome analysis that islets of Goto-Kakizaki (GK) rats, a model of spontaneous type 2 diabetes, overexp...
متن کاملTranscriptomic alterations in the heart of non-obese type 2 diabetic Goto-Kakizaki rats
BACKGROUND There is a spectacular rise in the global prevalence of type 2 diabetes mellitus (T2DM) due to the worldwide obesity epidemic. However, a significant proportion of T2DM patients are non-obese and they also have an increased risk of cardiovascular diseases. As the Goto-Kakizaki (GK) rat is a well-known model of non-obese T2DM, the goal of this study was to investigate the effect of no...
متن کاملTRANSLATIONAL PHYSIOLOGY Bladder and erectile dysfunctions in the Type 2 diabetic Goto-Kakizaki rat
Stephanie Oger-Roussel, Delphine Behr-Roussel, Stephanie Caisey, Micheline Kergoat, Christine Charon, Annick Audet, Jacques Bernabé, Laurent Alexandre, and Francois Giuliano Pelvipharm, Montigny-le-Bretonneux, France; Research group EA 4501-SIRIUS, Université Versailles Saint Quentin en Yvelines, Montigny Le Bretonneux, France; Metabrain Research, Chilly Mazarin, France; AP-HP, Neuro-Uro-Androl...
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ژورنال
عنوان ژورنال: Archives of Cardiovascular Diseases Supplements
سال: 2015
ISSN: 1878-6480
DOI: 10.1016/s1878-6480(15)30019-7